Termination of Aconitine-Induced Atrial Fibrillation by the KACh-Channel Blocker Tertiapin: Underlying Electrophysiological Mechanism
نویسندگان
چکیده
منابع مشابه
Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation.
One of the most exciting developments in our understanding of atrial fibrillation (AF) over the last several years has been the recognition that AF itself modifies atrial electrical properties in a way that promotes the occurrence and maintenance of the arrhythmia, a process termed 'atrial remodeling'. The principle stimulus for AF-induced atrial remodeling is the rapid atrial rate that results...
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Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concent...
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BACKGROUND The mechanisms underlying paroxysmal atrial flutter/atrial fibrillation initiation by ectopic foci from various locations are unclear. METHODS AND RESULTS We used parallel computational techniques to study an anatomically accurate 3-dimensional atrial structure incorporating a detailed ionic-current model of an atrial myocyte. At the single-cell level, upregulation of the L-type Ca...
متن کاملAre electrophysiological changes induced by longer lasting atrial fibrillation reversible? :observations using the atrial defibrillator.
BACKGROUND Studies in animal hearts have shown shortening of the atrial effective refractory period (AERP) and loss of the relation between the AERP and heart rate after prolonged periods of atrial fibrillation (AF). The purposes of this study were (1) to evaluate atrial electrophysiology after a long period of sinus rhythm in patients who had longer lasting recurrent AF that was successfully t...
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Objectives: Dual pathways have a determinant role in the occurrence of atrio nodal tachyarrhythmia (AVNRT). The aim of present study is to determine the role of slow pathway (SP) in the concealment zone and protective role of AV node during atrial fibrillation (AF). Material &Methods: In 7 isolated nodal rabbit preparation zone of concealment and concealed conduction is quantified by Specif...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2014
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.14023fp